Living Genome
Your DNA doesn't change.What science knows about it does.
Axolotl is designed to revisit your genomic data as databases, evidence and clinical knowledge evolve.
September 2026 update
Example genome · synthetic
- Evidence updates
- 27
- Worth reviewing
- 3
- SCN5A p.Arg1193GlnNew record
- TTN p.Pro20412SerEvidence
- RYR1 p.Thr2200MetEvidence
Four months, one genome
The same data, a different picture.
Nothing in the example genome changed between June and September. The evidence about it did, and each reanalysis records exactly what moved and why.
June 2026
Baseline genome analysis
- 3,842,193 variants indexed on GRCh38
- Evidence snapshot taken from public sources
July 2026
Evidence refresh
- 14 ClinVar evidence updates
- 2 new relevant submissions
August 2026
Reclassification
- 1 variant classification changed
- 5 evidence-strength changes
September 2026
LatestLatest reanalysis
- 27 evidence updates
- 3 variants worth reviewing
What changed?
Every change, with its source and date.
The example genome's reanalysis history. Select a row to open that variant in the Genome Explorer.
5 changes since June 2026
| Variant | Previous | Current | Change | When |
|---|---|---|---|---|
| LDLRp.Asp472Tyr | VUS | Likely benignNew functional evidence supported reclassification. | Classification | Aug 2026 |
| CYP2C19*2 (rs4244285) | 3 submissions | 6 submissionsMore submitters now report the same drug-response interpretation. | Evidence | Jul 2026 |
| SCN5Ap.Arg1193Gln | No record | VUSFirst submission for this variant. Worth reviewing. | New record | Sep 2026 |
| TTNp.Pro20412Ser | VUS (2 submissions) | Conflicting (4 submissions)Two new submissions disagree with the earlier ones. Worth reviewing. | Evidence | Sep 2026 |
| RYR1p.Thr2200Met | Not flagged | Review recommendedUpdated anaesthesia guidance now covers this gene. Worth reviewing. | Evidence | Sep 2026 |
Your genome stays the same
Sequenced or imported once, kept private in your Genome Vault.
Evidence keeps moving
Public databases, published studies and clinical guidelines are updated continually.
Axolotl re-checks it
Your variants are re-annotated against the latest evidence, with every source dated.
You see what changed
A short summary of what's different, with a genetics professional available when it matters.
All dates, counts and changes on this page are synthetic examples. Reanalysis explains published evidence; it does not independently diagnose disease.
Already have a genome?Give it a second life.
Early concept. No sequencing, testing or clinical services are offered yet.